Possible Interaction: Gamma-Aminobutyric Acid and Serine

“During treatment, an increase in the extracellular amino acids alanine, glycine, glutamate, aspartate, serine , threonine, and taurine was found demonstrating a significant influence on the intracellular pool of free amino acids induced by DAB.”

“Conversely, glycine and D‐serine , co‐agonists of NMDA receptors, enhanced the GABA release.”

“ GABA exposure also produces an increase in the serine phosphorylation on the GABAA receptor γ2 subunit.”

“Gamma amino butyric acid GABA ) and glutamate influence TH phosphorylation at serines 19 and 40, whereas cholinergic inputs affect its phosphorylation at serine 31.”

“Cerebral, hippocampal and cerebellar GABA levels were significantly higher in SER than the normal Kyo:Wistar and zitter rat (zi/zi), which were both the parent strains.”

“Turnover rates of the putative neurotransmitters (aspartate, glutamate, and GABA ) were 2–20‐fold higher than those of alanine and serine , and generally consistent with the proposed neurotransmitter functions for these amino acids.”

“ GABA enhanced the accumulation of amino acids (GABA, glycine, valine, proline, 5-oxoproline, serine , threonine, aspartic acid and glutamic acid) and organic acids (malic acid, lactic acid, gluconic acid, malonic acid and ribonic acid).”

“Metabolic profiling found … exogenous application of GABA led to increases in accumulations of amino … (glutamic acid, aspartic acid, alanine, threonine, serine , and valine), organic acids (aconitic acid, malic acid, succinic acid, oxalic acid, and threonic …), sugars (sucrose, fructose, glucose, galactose, and maltose), and sugar alcohols (mannitol and myo-inositol).”

“Interestingly, though amino acids such as alanine, histidine, proline and serine were not affected by liver diseases, but were significantly correlated with GABA level.”