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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“Concentration – response curves to GABA in the presence of SCS revealed a reduction in the maximum response with no change in the EC50 or Hill coefficient.”
Salicylidene salicylhydrazide, a selective inhibitor of β1‐containing GABAA receptors“Centrally, salicylate alters γ-aminobutyric acid (GABA) and serotonin mediated neurotransmission in the central nervous system (CNS), which results in classical and non-classical auditory regions showing hyperactivity after salicylate administration.”
“Our findings suggest that SS may preferentially target GABA neurons and consequently interrupt a normal level of GABAergic synaptic transmissions maintained by the serotonergic system in SS-induced tinnitus.”
“Tetrodotoxin at 0.5 microM produced a similar effect as SS did, suggesting that SS suppresses the 5-HT-induced enhancement of GABAergic sIPSCs through depressing spontaneous action potentials of GABA neurons.”
Sodium salicylate suppresses serotonin-induced enhancement of GABAergic spontaneous inhibitory postsynaptic currents in rat inferior colliculus in vitro
“ Salicylate significantly inhibited the amplitudes of both evoked and miniature inhibitory postsynaptic currents, and directly reduced gamma-aminobutyric acid type A (GABA(A)) receptor-mediated responses in cultured rat hippocampal neurons.”
“BACKGROUND Sodium salicylate SS ) induces excitotoxicity of spiral ganglion neurons (SGNs) by inhibiting the response of γ-aminobutyric acid type A receptors (GABAARs).”
Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons.“We found that perfusion of the slice with sodium salicylate decreased electrically evoked GABA receptor-mediated currents, increased paired-pulse ratio, and lowered frequency and amplitude of miniature inhibitory postsynaptic currents.”
“We found that perfusion of the slice with sodium salicylate decreased electrically evoked GABA receptor‐mediated currents, increased paired‐pulse ratio, and lowered frequency and amplitude of miniature inhibitory postsynaptic currents.”
“In planta SA and GABA biosynthesis increased concurrently.”
“The principal component correlated with salt stress was an antagonism of γ-aminobutyric and salicylic acid , confirming involvement of acid-sensing ion channels (ASICs) in salt stress sensing.”
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