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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Riluzole
Research Papers that Mention the Interaction
“Co-application of riluzole led to a slight decrease of absolute peak current amplitudes and steady-state currents in prolonged presence of GABA at saturating concentrations.”
“In the presence of riluzole , enhancement of current amplitudes was observed with lower concentrations of GABA at α1β2γ2s receptors and to a lower extent also at α1β2 receptors.”
Molecular mechanisms of interaction between the neuroprotective substance riluzole and GABAA-receptors“Both nipecotic acid (a classical blocker of GABA uptake) and riluzole were found to inhibit [3H]GABA uptake in a dose-related fashion (IC50 = 3.6 x 10(-6) M and 4.3 x 10(-5) M for nipecotic acid and riluzole, respectively).”
“These results indicate that, in addition to its antiglutamate properties, riluzole probably also promotes synaptic GABA accumulation, which might contribute to the anticonvulsant and/or anesthetic properties of this pharmacological agent.”
Riluzole, a novel antiglutamate, blocks GABA uptake by striatal synaptosomes.“Nevertheless, these results suggest that glutamate and GABA can be modulated with a single dose of riluzole.”
Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers: A randomized double-blind 7-Tesla pharmacological MRS study
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