Possible Interaction: Gamma-Aminobutyric Acid and Potassium Chloride

“Perfusion of KCl 100 mM produced a higher increase of extracellular glutamate and GABA in aged rats but not in young rats housed in an enriched environment compared to control rats.”

“Other depolarizing stimuli, such as exposure to 25 mM KCl , accelerate the switch of GABA from depolarizing to hyperpolarizing.”

“It was shown that a short-time application of GABA induces a decrease in the amplitude of calcium responses to subsequent addition of the depolarizing agents GABA or KCl.”

“ KCl at 70 mM at stimulated islet GABA release, subsequently decreasing its tissue concentration.”

“Infusion of KCl (50-100 mM) evoked a dose-dependent increase in GABA levels in the globus pallidus.”

“Following an intrastriatal KCl injection the GABA concentration increased and the glutamine concentration decreased in the corpus striatum.”

“After KCl stimulation the release of glutamate and GABA increased significantly in both groups.”

“Infusion of nipecotic acid or potassium chloride , resulted in a significant increase in extracellular GABA.”

“Perforated patch‐clamp recordings reveal that this depolarizing response is due to … reversal potential close to − 35 mV. When cells are grown in depolarizing potassium chloride concentrations, a shift … potential (Erev) for GABA is observed, and only 20% of the cells … by the neurotransmitter at day 5 in vitro.”

“In addition, GABA release was significantly increased by high K+ (100 mM KCl ) stimulation.”