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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Piperine
Research Papers that Mention the Interaction
“ Piperine , a natural compound isolated from the fruits of Piper, is known to modulate several neurotransmitter systems such as serotonin, norepinephrine, and GABA , all of which have been linked to the development of convulsions.”
Anticonvulsant mechanisms of piperine, a piperidine alkaloid“ Piperine increased striatal levels of GABA , glycine and taurine, and reversed pilocarpine-induced increases in nitrite contents in sera and brain.”
“ GABA plus piperine synergistically enhanced EPO and EPO‐R expression through p38 and c‐Jun N‐terminal kinase (JNK) MAPK signaling pathways, but not through the extracellular signal‐regulated kinase (ERK) MAPK pathway.”
Induction of functional erythropoietin and erythropoietin receptor gene expression by gamma‐aminobutyric acid and piperine in kidney epithelial cells“ Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates γ-aminobutyric acid type A receptors (GABAAR).”
“In unstressed mice, piperine significantly increased brain GABA levels, but could not produce any change in plasma nitrite levels.”
“Microarray results showed that GABA had a positive effect on the transcription of genes related to regulation of erythrocyte differentiation and that GABA and PIP in combination had a synergistic effect on genes related to immune systems and processes.”
Effects of gamma-aminobutyric acid and piperine on gene regulation in pig kidney epithelial cell lines
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