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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Pilocarpine

Research Papers that Mention the Interaction

The inhibitory effect produced by pilocarpine may involve the activation of GABAergic receptors, presumably through stimulation of GABAergic neurons and subsequent release of GABA.
Psychopharmacology  •  2004  |  View Paper
The SE was associated with a significant rise of GABA and glutamate release (up to 120 and 182% respectively, 5h after pilocarpine injection) and the prevalence of high-voltage rhythmic spikes and increased spectral potency of delta, gamma, and theta bands.
Epilepsy & Behavior  •  2015  |  View Paper
Evoked GABA release was increased by pilocarpine with a half-effective concentration of 53.8 microM. This increase could be attenuated by the M1-cholinoceptor antagonist pirenzepine (10 microM).
Toxicology letters  •  2005  |  View Paper
Administration of the nonselective agonist pilocarpine at 10 mM increased striatal dopamine release and decreased extracellular GABA and glutamate overflow.
Journal of neurochemistry  •  1997  |  View Paper
Pilocarpine initially decreased extracellular hippocampal glutamate and GABA levels.
British journal of pharmacology  •  1997  |  View Paper
The symptoms were blocked by atropine, scopolamine and the GABAergic agents GABA , sodium valproate, (+)-baclofen and clonazepam when given prior to pilocarpine , but not when administered 30 min after pilocarpine administration.
Methods and findings in experimental and clinical pharmacology  •  1996  |  View Paper
Cholinergic agonists, such as pilocarpine and tetramethylammonium, also attenuated significantly the evoked release of [3H]GABA from striatal slices, while none of its antagonists, including atropine, hexame‐thonium and d‐tubocurarine, affected the release.
Journal of neurochemistry  •  1984  |  View Paper
In the experiments on Wistar rats it was demonstrated that pilocarpine and physostigmine decreased the GABA level in the striatum.
Acta physiologica Polonica  •  1982  |  View Paper