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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Physostigmine
Research Papers that Mention the Interaction
“These chemicals included chemicals that could enhance transmission at cholinergic synapses physostigmine , nicotine), inhibit cholinergic transmission (atropine), stimulate or enhance the effects of GABA (diazepam, muscimol, cis‐4‐aminocrotonic acid), or antagonise the action of GABA (picrotoxin, bicuculline, SR95531).”
Progress toward Understanding the Neurophysiological Basis of Predator‐Induced Morphology in Daphnia pulex“Under these experimental conditions, acetylcholine (0.1-10 microM) and physostigmine (30 microM) decreased the electrically evoked GABA release while the M2 receptor antagonist AFDX-116 (0.01-0.1 microM) counteracted these effects.”
“Subeffective dose of GABA , when combined with physostigmine , further delayed the latency to reach SFZ, but reduced the number of mistakes very significantly.”
“ Physostigmine induced a significant decrease in striatal GABA level and a reduction of synthesis index in the rest of the brain while organophosphates have little or no effect on GABA level and metabolism.”
“In the experiments on Wistar rats it was demonstrated that pilocarpine and physostigmine decreased the GABA level in the striatum.”
“The threshold, was increased by GABA which also potentiated the effect of physostigmine and antagonized that of atropine.”
“On the background of the two higher physostigmine doses , however, the anticonvulsive effect of GABA is markedly decreased.”
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