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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Phenylephrine
Research Papers that Mention the Interaction
“ Phe increases GABA release probability and the number of releasable vesicles.”
Stimulation of α1-adrenoceptors facilitates GABAergic transmission onto pyramidal neurons in the medial prefrontal cortex“Similar injections of phenylephrine and yohimbine reduced anxiety in threatening situation task only, while GABA reduced it in both tasks.”
“In sham-operated rats, intravenous infusion of phenylephrine increased blood pressure and the hypothalamic release of GABA and taurine.”
“3H-IP formation induced by phenylephrine and methoxamine was also potentiated by GABA , and again the greatest effect was on [3H]IP2 accumulation.”
“The release of GABA was increased by phenylephrine in a concentration-dependent (0.01-1 microM) manner.”
“On the other hand, local administration of the alpha agonist, PE , routinely produced NE-like antagonism of GABA inhibition along with increases in spontaneous firing rate.”
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