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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Phenylephrine

Research Papers that Mention the Interaction

Phe increases GABA release probability and the number of releasable vesicles.
Neuroscience  •  2015  |  View Paper
Similar injections of phenylephrine and yohimbine reduced anxiety in threatening situation task only, while GABA reduced it in both tasks.
Bulletin of Experimental Biology and Medicine  •  2004  |  View Paper
In sham-operated rats, intravenous infusion of phenylephrine increased blood pressure and the hypothalamic release of GABA and taurine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1997  |  View Paper
3H-IP formation induced by phenylephrine and methoxamine was also potentiated by GABA , and again the greatest effect was on [3H]IP2 accumulation.
Journal of neurochemistry  •  1990  |  View Paper
The release of GABA was increased by phenylephrine in a concentration-dependent (0.01-1 microM) manner.
The Journal of pharmacology and experimental therapeutics  •  1988  |  View Paper
On the other hand, local administration of the alpha agonist, PE , routinely produced NE-like antagonism of GABA inhibition along with increases in spontaneous firing rate.
Brain Research  •  1988  |  View Paper