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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Pentobarbital
Research Papers that Mention the Interaction
“ GABA co-application potentiated PB blockade.”
Pentobarbital Produces Activation and Block of α1β2γ2S GABAA Receptors in Rapidly Perfused Whole Cells and Membrane Patches: Divergent Results Can Be Explained by Pharmacokinetics“Addition of millimolar concentrations of PB in the presence of GABA also produces a reduction of open channel lifetime in addition to a progressive increase in the closed interval durations within a cluster.”
“In cells infected with both alpha 1 and beta 1 recombinant viruses, GABA elicited an outwardly rectifying chloride current that was blocked by bicuculline and potentiated by pentobarbitone.”
“Currents evoked by a saturating concentration of GABA or by co-application of GABA and pentobarbital were recorded using the patch clamp technique.”
“Specifically, with saturating concentrations of GABA, pentobarbital substantially potentiated peak α1β3δ receptor currents but failed to potentiate peak α1β3γ2L receptor currents.”
“Diazepam (10 microM) and pentobarbital (10 microM) upmodulated the GABA current by approximately 149 and 168%, respectively.”
“ Pentobarbital , propofol, or diazepam elevate and picrotoxin or furosemide eliminate the effect of GABA on the Cl–-transport processes.”
Dual character of GABA action on Cl–-transport by the reconstituted Cl–/-ATPase from rat brain“ Pentobarbital potentiates γ-aminobutyric acid (GABA)-mediated inhibitory synaptic transmission by prolonging the open time of GABAA receptors.”
“Moreover, PB facilitates GABAA receptor activation by GABA , and it is commonly prescribed for strychnine poison.”
“The barbiturate pentobarbital binds to gamma-aminobutyric acid type A (GABA(A)) receptors, and this interaction plays an important role in the anesthetic action of this drug.”
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