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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Penicillins
Research Papers that Mention the Interaction
“ Penicillin , a second component of the injection may contribute to the development of kindling by its properties of antagonizing GABA neurotransmission.”
Hoigné's syndrome: a procaine-induced limbic kindling.“The neurotoxicity of penicillin was first reported in 1945 by Johnson and Walker and is believed to exert an inhibitory effect on gamma-aminobutyric acid transmission of cortical pyramidal cells, due to its beta-lactam ring structure.”
“Interestingly, while currents evoked from synaptic isoforms under phasic conditions (transient activation by a saturating concentration of GABA ) were substantially inhibited by penicillin , currents evoked from extrasynaptic isoforms under tonic conditions (prolonged application by a sub-saturating concentration of GABA) were minimally affected.”
“When co-applied with saturating GABA, penicillin decreased peak amplitude, induced rebound, and prolonged deactivation of currents evoked from both synaptic and extrasynaptic receptor isoforms.”
“ Penicillin also reduced the maximum … to iontophoretically applied GABA without affecting the dose required to obtain a half-maximal response, suggesting a noncompetitive antagonism.4.Pentobarbital (100–200µM) prolonged … time course and increased the amplitude of the IPSPs while producing a leftward shift in the GABA charge-response relation.”
Interaction of penicillin and pentobarbital with inhibitory synaptic mechanisms in neocortex“The IAA, r-aminobutyric acid (GABA), glycine, and taurine levels increased significantly after injection of 1336 u of PC.”
“Partial blockade of gamma-aminobutyric acidA (GABAA)-mediated inhibition by 500 IU/ml penicillin produced low frequency (2-4 Hz) "pro-convulsant" field potential oscillations.”
“Responses to GABA were antagonized by bicuculline, picrotoxin and penicillin.”
“In comparison, the inhibitory effect of penicillin on GABAA receptor is enhanced by increasing GABA concentration.”
“ Penicillin , a Cl- channel blocker, antagonized the action of GABA and glycine, while increasing the amplitude of the U2 waveform.”
“Bicuculline and penicillin antagonized the action of GABA at all investigated levels of CA1 pyramidal cells.”
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