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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Pargyline

Research Papers that Mention the Interaction

Pretreatment with pargyline , a potent inhibitor of monoamine oxidase (EC 1.4.3.4) abolishes the effects on 4-aminobutyric acid metabolism and potentiates the inhibitory effect of 5-hexyne-1.4-diamine on prostatic ornithine decarboxylase activity.
Biochemical pharmacology  •  1979  |  View Paper
Pargyline and desipramine increased the brain concentration of GABA but were without effect on GABA production.
General pharmacology  •  1976  |  View Paper
Abstract In mice, intraperitoneal administration of desipramine (12·5–100 mg/kg) or pargyline (25–200 mg/kg) reliably elevated the brain concentration of gamma-aminobutyric acid in a dose-dependent manner.
Biochemical pharmacology  •  1975  |  View Paper