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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Oxytocin

supplement:

Oxytocin

Research Papers that Mention the Interaction

In the immature rat hippocampal and neocortical neurons at birth, endogenous OXT induced a switch in the action of GABA from excitatory to inhibitory.
Progress in brain research  •  2008  |  View Paper
The GABA innervation appears to play a role in patterning the pulsatile discharge of oxytocin cells that is observed both during parturition and during suckling-induced reflex milk ejection (Moos, 1995; Voisin et al. 1995).
The Journal of physiology  •  1999  |  View Paper
Animal and early fetal developmental studies suggest an inter-dependent role of oxytocin and GABA in regulating social behaviors.
Progress in brain research  •  2019  |  View Paper
Oxytocin also prominently directs the transition of neuronal GABA neurotransmission from excitatory to inhibitory after birth.
Journal of psychiatric research  •  2018  |  View Paper
During a brief period from just before to just after birth, maternal oxytocin temporarily renders GABA inhibitory, possibly by reducing NKCC1 activity, which protects the developing brain from peripartum hypoxic insults.
Anesthesiology  •  2010  |  View Paper
It is possible that nitric oxide, but not GABA , may contribute to the feedback system of OXT neurons in chronic inflammation.
Molecular pain  •  2020  |  View Paper
In this regard, at the cortical level, oxytocin can modulate the GABAergic transmission; consequently, an interaction modulating nociception could exist between oxytocin and GABA at RAIC.
The Journal of Neuroscience  •  2020  |  View Paper
Oxytocin release causes an increase in the neurotransmitters noradrenaline, acetylcholine, glutamate and γ-aminobutyric acid (GABA) in the olfactory bulb, and other brain regions important for maternal behaviour.
Animal : an international journal of animal bioscience  •  2014  |  View Paper
OT increased the basal levels of extracellular GABA in mPFC and DHC of mice, and inhibited the MAP‐induced GABA decrease in DHC.
Addiction biology  •  2012  |  View Paper
In vitro, oxytocin induces a massive release of GABA from neurons in the lateral division of the central amygdala which results in inhibition of a subpopulation of peripherally projecting neurons in the medial division of the central amygdala (CeM).
Neuropharmacology  •  2010  |  View Paper
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