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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Oxazepam

Research Papers that Mention the Interaction

GABA enhanced the [3H]diazepam-displacing potencies of the 3S-enantiomers of the acetate, hemisuccinate, and (S)-alpha-methyl-beta-phenyl-propionate esters of oxazepam by a factor of about 1.5-1.6, whereas the GABA shifts for 3R-esters were about 1.2.
Molecular pharmacology  •  1991  |  View Paper
3) It raised the sensitivity to the acute administration of oxazepam (by 18-29.4%), but weakened the inhibitory effect of gamma-aminobutyric acid (by 17.6-33.2%).
Physiologia Bohemoslovaca  •  1988  |  View Paper
Gaba increases the potency of the benzodiazepines chlordiazepoxide, clonazepam, diazepam, nitrazepam and oxazepam , and the triazolopyridazine CL 218,872 in displacing specific binding of the benzodiazepine antagonist [3H]Ro 15-1788.
Neuroscience Letters  •  1982  |  View Paper
Oxazepam is a benzodiazepine that enhances the effects of γ-aminobutyric acid on the brain and nerves to produce a calming effect; it can cause drowsiness and dizziness, especially in elderly people.
Canadian Urological Association journal = Journal de l'Association des urologues du Canada  •  2008  |  View Paper