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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Ondansetron

Research Papers that Mention the Interaction

IGABA and I5‐HT were inhibited by bicuculline and ondansetron , respectively.
Synapse  •  2007  |  View Paper
Like clozapine, ondansetron partially reverses the inhibitory effect of GABA on [35S]TBPS binding.
Neurochemical Research  •  2004  |  View Paper
Inhibition of anxiolytic activity of ondansetron (5-HT3 receptor antagonist), buspirone (5-HT1A receptor agonist), and diazepam [acting on gamma-aminobutyric acid (GABAA) receptor] suggests a nonspecific anxiogenic activity of TM and also a link between 5-HT and GABA systems in the anxiogenic activity of TM.
Pharmacology Biochemistry and Behavior  •  2002  |  View Paper
Bicuculline (0.5 mM, n = 27) and ondansetron (1.0 mM, n = 10) blocked the GABA and PBG effects, respectively (P < 0.05).
Journal of neurophysiology  •  2001  |  View Paper
However, the inhibitory effect … more potent when ondansetron was co-applied with lower concentrations of GABA : i.e., the ondansetron concentration needed to depress the current induced by 5 microM GABA to half amplitude was 7 microM compared to 28 microM for the current induced by 10 microM GABA.
European journal of pharmacology  •  1997  |  View Paper