supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Ondansetron
Research Papers that Mention the Interaction
“ IGABA and I5‐HT were inhibited by bicuculline and ondansetron , respectively.”
Cross‐talking between 5‐HT3 and GABAA receptors in cultured myenteric neurons“Like clozapine, ondansetron partially reverses the inhibitory effect of GABA on [35S]TBPS binding.”
“Inhibition of anxiolytic activity of ondansetron (5-HT3 receptor antagonist), buspirone (5-HT1A receptor agonist), and diazepam [acting on gamma-aminobutyric acid (GABAA) receptor] suggests a nonspecific anxiogenic activity of TM and also a link between 5-HT and GABA systems in the anxiogenic activity of TM.”
“Bicuculline (0.5 mM, n = 27) and ondansetron (1.0 mM, n = 10) blocked the GABA and PBG effects, respectively (P < 0.05).”
“However, the inhibitory effect … more potent when ondansetron was co-applied with lower concentrations of GABA : i.e., the ondansetron concentration needed to depress the current induced by 5 microM GABA to half amplitude was 7 microM compared to 28 microM for the current induced by 10 microM GABA.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback