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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Nitrous Oxide
Research Papers that Mention the Interaction
“Like ketamine, which has a similar action on these receptors, nitrous oxide causes a neurotoxic reaction in rat brain that can be prevented by use of a c-amino-butyric acid ( GABA ) agonist such as a benzodiazepine, barbiturate, propofol, or an inhaled ether anaesthetic [22].”
Nitrous oxide or remifentanil for the ‘at risk’ brain“The present results indicated that N2O inhibits the activation of AMPA/KA and NMDA receptors and also that N2O preferentially depress the action potential-dependent GABA and glutamate releases but had little effects on spontaneous and miniature releases.”
Nitrous oxide directly inhibits action potential-dependent neurotransmission from single presynaptic boutons adhering to rat hippocampal CA3 neurons“ Nitrous oxide at 1.5 atm (the ED50 for loss of righting reflex in mice) and at 3 atm, significantly depressed the responses to GABA and to the nicotinic agonist, but did not alter the responses to methylfurmethide.”
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