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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Nitroprusside
Research Papers that Mention the Interaction
“The results of these studies showed that NO released from SNP (2.5 mg/kg) had a potential to inhibit GABA-T activity resulting in an increase in the concentration of GABA in the brain.”
Effects of sodium nitroprusside, a nitric oxide donor, on γ-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats“The NO-generating compounds S-nitroso-N-acetylpenicillamine (SNAP), sodiumnitroprusside and hydroxylamine enhanced the basal GABA release.”
“Perfusion with 0.5 or 5 mM sodium nitroprusside significantly reduced high K(+)-evoked GABA release.”
“These results demonstrate that sodium nitroprusside reduces high K(+)-evoked GABA release both via an NO/cyclic GMP-dependent pathway and via an NO-dependent, but cyclic GMP-independent, pathway in rat hippocampus in vivo.”
“In amphotericin B‐perforated cells incubated with the soluble guanylyl cyclase inhibitors LY 83583 and ODQ (10−4 M each), the NO donor sodium nitroprusside SNP ) (10−3 M) reversibly increased the current evoked by GABA (5 × 10−6 M).”
“In outside‐out patches, incubation with SNP also significantly enhanced the open probability of single channels activated by GABA (10−6 M).”
“… SNP … GABA (-1.05 +/- 0.17nA vs. -0.63 +/- 0.11nA, n = 22, p < 0.01 or 0.1 mM muscimol a specific GABA(A) receptor ….24 nA, n = 6, p < 0.05), which could be cancelled by simultaneous application of 1 mM methylene blue, an inhibitor of PKG.”
“ Sodium nitroprusside (0.5 mM), an NO releaser, had no effect on basal GABA release but significantly decreased K(+)-evoked GABA release.”
“Because GABA inhibits both nitroprusside (NP-induced PGE2 and LHRH release by blocking the activation of cyclooxygenase by NO, this is another mechanism by which beta-endorphin inhibits NP-induced PGE2 and LHRH release.”
“It is concluded that NO generated from sodium nitroprusside in the spinal cord exerts inhibitory and excitatory effects on blood pressure probably through the release of GABA and glutamate, respectively.”
“Baroreceptor unloading evoked either by intravenous infusion of nitroprusside , or by haemorrhage, decreased the release rates of GABA and taurine in sham-operated rats but not in AD rats.”
“ Sodium nitroprusside (NP) (300 microM), a spontaneous releaser of NO, doubled the release of GABA.”
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