Possible Interaction: Gamma-Aminobutyric Acid and Nitric Oxide

“Endogenous NO modulates the release of acetylcholine, glutamate, aspartate, GABA , serotonin, histamine in distinct brain areas.”

“This action seems to employ an indirect mechanism by which NO may modulate the release of GABA.”

“In particular, NO heavily influences the excitatory neurotransmitter glutamate, mainly through NMDA receptors, and the inhibitory neurotransmitter GABA , mainly through GABA A receptors.”

“Collectively, these results suggest that short repeated oral administration of GABA has an anxiolytic-like effect possibly via preventing NO reduction caused by stress and improving availability of NO in the frontal cortex.”

“Nitric oxide NO ) production has correlation with GABA and regulates GnRH secretion.”

“Ex vivo NO modified GABA-T activity and GABA levels biphasically.”

“In vitro NO diminished GABA-T activity and increased GABA.”

“Together, these results suggest that NO promotes GABA release by activating TRPC5 channels in AC dendrites.”

“ NO subsequently acts presynaptically to enhance GABA release through a soluble guanylate cyclase-mediated pathway.”

“Further pharmacological experiments, such as the application of a nitric oxide-sensitive guanylyl cyclase (NO-sGC) receptor antagonist, a NOS inhibitor, and NO donors, suggested that NO released from postsynaptic cells mediated FSI and likely activated presynaptic receptors to inhibit GABA release.”

“Conclusions Our results indicate that NO induces release of aspartate, glutamate, glycine and GABA in cortical neurons and that this release is inhibited by ODQ, an inhibitor of soluble guanylate cyclase.”