Possible Interaction: Gamma-Aminobutyric Acid and Nifedipine

“The blocker of potential-dependent calcium channels nifedipine suppressed simultaneously the amplitudes of calcium responses to the addition of KCl and GABA.”

“The L‐type calcium channel blocker, nifedipine , also inhibited the release of [3H]‐GABA and coapplication with NAAG resulted in no significant additional inhibition of release.”

“The ability of progesterone, GABA , or muscimol to stimulate exocytosis was blocked by the Ca2+ channel antagonists verapamil or nifedipine.”

“The GABA or muscimol effect on [Ca2+]i was antagonized by nifedipine (10 microM) or verapamil (50 microM), and completely abolished in the presence of 4 mM EGTA (low-calcium medium).”

“Hexamethonium and nifedipine decreased concentrations of GABA in all the regions studied, while concentrations of glycine, beta-alanine and taurine were not affected by these agents.”

“ Nifedipine completely blocked the GABA or isoguvacine potentiation of the TSH response while omega-conotoxin did not modify it.”

“Incubation in the presence of nifedipine (1 microM) or in calcium-free medium inhibited the LH-releasing action of GABA , indicating that calcium influx through voltage-sensitive calcium channels (VSCC) is required for GABA-induced LH release.”

“ Nifedipine reduced the 45Ca2+ uptake and CA release induced by GABA.”

“ Nifedipine per-se had no effect on GABA levels in the brain stem but it partially antagonized ALP-induced inhibitory effect on GABA in this region.”