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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“But in the presence of L-NAME , a nitric oxide synthesis inhibitor, although GABA- induced vasorelaxation was not suppressed at a dose of 1 µM of GABA in all groups, this response was suppressed with the other doses of GABA.”
“Both the inhibitory and excitatory effects of GABA were blocked by TTX and L-NAME + apamin; the GABA-induced contraction was also sensitive to L 732-138.”
“An NO decreasing dose of nitric oxide synthase (NOS) inhibitor, N-nitro-L-arginine methyl ester (L-NAME) decreased brain GABA concentration and increased the convulsant action of picrotoxin.”
“Our findings tend to indicate that the change of behavioral state observed after systemic or intra-DRN administration of L-NAME is partly related to the reduction of GABA and adenosine at critical sites in the CNS.”
“L-NMMA (0.3 mM) and L-NAME (0.5 mM) increased K(+)-evoked GABA release, indicating that NO plays an inhibitory role in GABA release from PP.”
“The inhibition in both basal and K(+)-evoked GABA release induced by NKA (10(-7) M) was reduced by L-NAME (1 mM).”
“The NOS inhibitors L-NAME and L-NOARG reduced in a concentration-dependent manner nerve-mediated relaxations elicited by TES, nicotine and GABA.”
“1.0 mM L-NAME significantly decreased basal extracellular GABA , while abolishing the NMDA-evoked release of the amino acid.”
“The nitric oxide synthase inhibitor L-nitro-arginine-methyl ester (L-NAME; 100 microM) increased basal GABA release, and also enhanced release of GABA evoked by NMDA (100 microM) compared with the same concentration of NMDA infused alone.”
Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo“The inhibitor of L-arginine-NO synthase N omega-Nitro-L-arginine methyl ester L-NAME ) (10(-4)-3 x 10(-4) M) reduced the NANC relaxations elicited by GABA and low frequency electrical stimulation in a dose-dependent manner.”
“On the other hand, NO seems to be involved in the inhibitory effect of GABA on prolactin release since hemoglobin, a scavenger of NO, and Nw‐nitro‐L‐arginine methyl ester , an inhibitor of NO synthase (NOS), blocked the pituitary response to GABA.”
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