Possible Interaction: Gamma-Aminobutyric Acid and Neuromuscular Depolarizing Agents

“In this article, we review these major recent findings and argue that both depolarizing and inhibitory GABA actions may be crucial for physiological brain maturation.”

“Other depolarizing stimuli, such as exposure to 25 mM KCl, accelerate the switch of GABA from depolarizing to hyperpolarizing.”

“It was shown that a short-time application of GABA induces a decrease in the amplitude of calcium responses to subsequent addition of the depolarizing agents GABA or KCl.”

“ GABA depolarization could lead to an increase in spikes either independently or in summation with other depolarizing stimuli, or alternately, depending on the relative timing of other depolarizing events, could lead to shunting inhibition.”

“Reduction in the depolarizing GABA driving force was due to a progressive negative shift of the reversal potential of GABA currents.”

“This increased mossy fiber excitability caused by depolarizing action of GABA gradually decreased with development and eventually disappeared at around postnatal day 30.”

“The resting membrane potential estimated from the reversal of N‐methyl‐d‐aspartate‐induced single‐channel currents in cell‐attach experiments was −75 mV. In spite of its depolarizing action , in the majority of cases GABA was still inhibitory as it blocked the firing of principal cells.”

“ GABA also elicited a depolarizing response.”

“Pretreatment with 1 mM GABA , before perfusion with depolarizing agents , significantly suppressed the depolarizing agent-induced increase in glutamate levels.”

“ GABA also shifted to depolarized values (>5 mV) the S-shaped plots of the peak ICa evoked by a constant depolarizing pulse as a function of prepulse voltage (i.e., inactivation curves) and accelerated the recovery time from the inactivation evoked by depolarizing prepulses (>35%).”