Possible Interaction: Gamma-Aminobutyric Acid and Nerve Growth Factor

“These results suggest that the administration of GABA to ovariectomized female rats is likely to control the mRNA level and concentration of NGF and cause an increase in the activity of choline acetyltransferase in the brains.”

“In addition, we show that acute exposure to NGF , via activation of TrkA, attenuates GABAA receptor-mediated inhibitory synaptic currents and reduces sensitivity to exogenously applied GABA.”

“Moreover, GABA induced a 20% increase in NGF secretion to the growth medium, in a similar time frame to its effect on growth.”

“Morphometric analysis showed that NGF and/or dbcAMP treatment substantially increased the insulin and GABA content in granules and rough endoplasmic reticulum.”

“Immunohistochemistry of E13 spinal cord sections indicates that NGF and GABA colocalize in fibers close to the target destinations of migrating neurons, suggesting diffusible gradients of these molecules provide chemoattractant signals to migratory cells.”

“NASs modulate many processes via interacting with gamma-aminobutyric acid (GABA), N-methyl-d-aspartate, serotonin, voltage-gated calcium channels, voltage-dependent anion channels, α-adrenoreceptors, X-receptors of the liver, transient receptor potential channels, microtubule-associated protein 2, neurotrophin nerve growth factor , and σ1 receptors.”