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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Naloxone
Research Papers that Mention the Interaction
“Systemic injection of naloxone NAL ) increases LH secretion in male rats, an effect which can be prevented by coadministration of GABA agonists.”
The inhibitory effect of beta-endorphin on LH release in ovariectomized rats does not involve the preoptic GABAergic system.“Folic acid, pentazocine and naloxone also reversed the inhibitory effect of GABA on [3H]TBOB binding.”
“Pretreatment with naloxone (10 mg/kg) significantly attenuated the inhibitory effect of GABA (100 micrograms) on AVP release.”
“Electrical stimulation of the locus ceruleus or naloxone treatment reduced the release of gamma-aminobutyric acid (GABA) from the exposed parietal cortex of morphine-tolerant guinea pigs.”
“In addition, we were interested in seeing what effect the GABA antagonist, bicucculine (Bic), had on cerebral function during relative ischaemia, because Nal in high doses is suspected to antagonize GABA transmission.”
“Application of bicuculline also greatly antagonized the effect of morphine, but the blocking effect of GABA on the evoked bradycardia and depressor responses still existed following the pretreatment of naloxone.”
“A third possibility, raised from other recent work, is that the excitatory effects of naloxone may have been due to an antagonism of the effects of γ-aminobutyrate in the spinal cord.”
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