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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Muscimol
Research Papers that Mention the Interaction
“These results indicate that the contralateral circling behavior induced by intranigral injections of GABA and muscimol seems to be dependent both on the activation of the dopaminergic nigrostriatal system and on the nondopaminergic nigral output system.”
Circling behavior induced by intranigral injections of GABA and muscimol in rats“Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting.”
“The capacitating effect of GABA was mimicked by a GABAA receptor agonist muscimol.”
“The addition of GABA and the GABA A type receptor agonist, Muscimol , promoted cell proliferation and inhibited cell apoptosis through the activation of the p38 MAPK and the inhibition of the JNK MAPK signaling pathways.”
“There was significantly increased CA1 excitatory output in the sevoflurane treated group compared to the no sevoflurane treated group after the GABA agonist muscimol.”
Exposure to Sevoflurane, But Not Ketamine, During Early-life Brain Development has Long-Lasting Effects on GABAA Receptor Mediated Inhibitory Neurotransmission“Reversible inactivation of neural activity in dorsolateral but not dorsomedial striatum using the GABA agonists muscimol and baclofen decreased context-induced reinstatement.”
“Smaller effects were seen on the endogenous GABA concentration in the substantia nigra, since both the synthesis and the utilization of GABA were decreased by muscimol and baclofen.”
“The GABA agonists, muscimol , baclofen and THIP decreased the accumulation of GABA following inhibition of GABA-α-ketoglutaric acid aminotransferase byγ-acetylenic GABA (GAG) in both structures investigated.”
“Brainstem stimulated locomotion (both chemically and electrically induced) could be transiently blocked by intracerebral infusion of GABA and irreversibly blocked by muscimol (GABAA agonist).”
“There was a substantial increase of GnRH-… and GnRH-III following treatment of muscimol at 100 microM. In in vivo studies, GABA or muscimol injected at 200 microg/kg significantly increased lamprey GnRH concentration in the brain 0.5 h after treatment compared to controls in female sea lampreys.”
“ Muscimol is a weak, non-competitive inhibitor (Ki1.2×10−3 M) of the uptake of γ-aminobutyric acid by slices of rat cerebral cortex.”
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