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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Gamma-Aminobutyric Acid and Moxidectin

Research Papers that Mention the Interaction

Our data show that MOX potentiated tonic GABA currents in a dose-dependent manner but had no concomitant effects on phasic GABA currents (i.e., MOX had no effect on the amplitude, frequency, or decay kinetics of mIPSCs).
Journal of neurophysiology  •  2018  |  View Paper
The anthelmintics ivermectin and moxidectin both moderately potentiated the activation of Hco-UNC-49 by GABA , while piperazine was able to directly activate both the Hco-UNC-49 homomeric and heteromeric channels with EC(50) values of 6.23 ± 0.45 mM and 5.09 ± 0.32 mM, respectively.
Veterinary parasitology  •  2012  |  View Paper
Moxidectin exerts its neurotoxic effects in mammals by potentiating the effect of gamma-aminobutyric acid and, consistent with this, both the dogs demonstrated a poor response to treatment with diazepam.
The Journal of small animal practice  •  2006  |  View Paper