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Last Updated: 3 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Modafinil

supplement:

Gamma-Aminobutyric Acid

drug:

Modafinil

Research Papers that Mention the Interaction

“Aims/hypothesisOur hypothesis is that reducing release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with modafinil will enhance symptomatic and hormonal responses to hypoglycaemia.”
The effect of modafinil on counter-regulatory and cognitive responses to hypoglycaemia
Diabetologia  •  2004  |  View Paper
“Animals were then exposed ... In addition to this possible glutamate-mediated mechanism, modafinil is reported to affect other neurotransmitter systems such as catecholamines, serotonin, GABA , orexin, and histamine.”
Modafinil: an anti-relapse medication
Neuropsychopharmacology  •  2010  |  View Paper
“Although modafinil is reported to reduce GABA-activated currents and extracellular GABA levels in the brain, the drug exerts anticonvulsant effects in animal studies.”
Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model
Psychopharmacology  •  2015  |  View Paper
“These findings show that modafinil increases glutamate and decreases GABA levels in MPA and PH.”
The Vigilance Promoting Drug Modafinil Increases Extracellular Glutamate Levels in the Medial Preoptic Area and the Posterior Hypothalamus of the Conscious Rat: Prevention by Local GABAA Receptor Blockade
Neuropsychopharmacology  •  1999  |  View Paper
“At the highest dose (300 mg/kg), modafinil induced a further reduction of pallidal (75+/-2%) but not striatal (82+/-7%) GABA release and increased striatal (134+/-11%) but not pallidal glutamate release.”
“The preferential reduction in striato-pallidal GABA release at the 100 mg/kg dose of modafinil suggests that modafinil may be useful in the treatment of Parkinsonian diseases.”
The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission
Neuroscience Letters  •  1998  |  View Paper
“The GABA release inhibition by modafinil in the above areas may be relevant for its vigilance promoting action.”
The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rat: possible involvement of the serotonergic 5-HT3 receptor
Neuroscience Letters  •  1996  |  View Paper
“The catecholaminergic telencephalic networks therefore seem essential for the elicitation of the inhibitory effects of modafinil on GABA release.”
“The results show that repeated daily modafinil treatment produces a similar but short-lasting reduction of GABA outflow compared with acute administration.”
6-Hydroxy-dopamine treatment counteracts the reduction of cortical GABA release produced by the vigilance promoting drug modafinil in the awake freely moving guinea-pig
Neuroscience Letters  •  1994  |  View Paper