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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Metoclopramide
Research Papers that Mention the Interaction
“ MCP induced a concentration dependent enhancement of electrically induced twitch responses of the myenteric plexus and this effect was further intensified by arecaidine and L-2, 4-diaminobutyric acid (L-DABA; GABA uptake inhibitors) and ethylenediamine (EDA; GABA releasing agent).”
“The study indicates that GABA plays a role in the facilitatory effect of MCP on both stimulated and unstimulated preparations of guinea pig myenteric plexus.”
“The MCP induced contraction of the unstimulated preparation was also reduced after GABA desensitization and EDA without affecting responses to exogenous acetylcholine (ACh).”
Involvement of gamma-aminobutyric acid in the stimulatory effect of metoclopramide on gastrointestinal motility.“Higher amounts (10 microM) of SCH 23390, metoclopramide , or other D2 antagonists (loxapine, haloperidol) reduced evoked GABA release by themselves, probably by nonspecific mechanisms.”
“Subthreshold doses of haloperidol, sultopride, metoclopramide and pimozide failed to consistently antagonise peri-oral movements when similarly combined with GABA , serotonin or quipazine.”
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