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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Metoclopramide

Research Papers that Mention the Interaction

MCP induced a concentration dependent enhancement of electrically induced twitch responses of the myenteric plexus and this effect was further intensified by arecaidine and L-2, 4-diaminobutyric acid (L-DABA; GABA uptake inhibitors) and ethylenediamine (EDA; GABA releasing agent).
The study indicates that GABA plays a role in the facilitatory effect of MCP on both stimulated and unstimulated preparations of guinea pig myenteric plexus.
The MCP induced contraction of the unstimulated preparation was also reduced after GABA desensitization and EDA without affecting responses to exogenous acetylcholine (ACh).
Life sciences  •  1994  |  View Paper
Higher amounts (10 microM) of SCH 23390, metoclopramide , or other D2 antagonists (loxapine, haloperidol) reduced evoked GABA release by themselves, probably by nonspecific mechanisms.
Journal of neurochemistry  •  1987  |  View Paper
Subthreshold doses of haloperidol, sultopride, metoclopramide and pimozide failed to consistently antagonise peri-oral movements when similarly combined with GABA , serotonin or quipazine.
European journal of pharmacology  •  1978  |  View Paper