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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Methylphenidate
Research Papers that Mention the Interaction
“In contrast we found that GABA agonists potentiate stereotyped gnawing induced by methylphenidate.”
Decreased antistereotypic effect of neuroliptics after additional treatment with a benzodiazepine, a GABA agonist or an anticholinergic compound.“Conversely, levels of some metabolites associated with inhibitory neurotransmission, including GABA and glycine were reduced by acute (5.0 mg/kg) MPH , together with acetate, aspartate and hypoxanthine.”
Methylphenidate alters monoaminergic and metabolic pathways in the cerebellum of adolescent rats“Acute MPH treatment increased the levels of a number of cerebral metabolites, including amino acid transmitters (e.g. GABA and glutamate) and aromatic amino acids (e.g. tyrosine and phenylalanine).The upregulated metabolites may elevate both cerebral excitatory and inhibitory neurotransmission processes.”
“ Methylphenidate inhibited [3H]GABA release showing that the nRt contains sufficient endogenous dopamine to activate D4 receptors.”
“Both methylphenidate and methamphetamine, dopamine reuptake blockers, inhibited by 30% high K(+)-evoked GABA release; the inhibition was blocked by L-745,870.”
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