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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Gamma-Aminobutyric Acid and Methohexital

Research Papers that Mention the Interaction

By binding to its own receptor on the complex, methohexital augments the inhibitory effect of GABA on neurons and additionally can exert a similar effect independent of GABA.
Anesthesia progress  •  1991  |  View Paper
Perfusion of slices with 10 to 100 microM MTH caused no significant change in glutamatergic transmission in the hippocampal CA1 region, but enhanced gamma-aminobutyric acid (GABA)A-mediated inhibitory postsynaptic currents and induced spontaneous inhibitory postsynaptic currents in neocortical and hippocampal CA1 neurons.
The Journal of pharmacology and experimental therapeutics  •  1998  |  View Paper
2 A high, supra‐anaesthetic concentration of methohexitone increased the uptake of both d‐aspartate and GABA.
British journal of pharmacology  •  1982  |  View Paper
4 Thiopentone, pentobarbitone, methohexitone and hydroxydione inhibited K+‐stimulated GABA and D‐aspartate release.
British journal of pharmacology  •  1981  |  View Paper