supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Methohexital
Research Papers that Mention the Interaction
“By binding to its own receptor on the complex, methohexital augments the inhibitory effect of GABA on neurons and additionally can exert a similar effect independent of GABA.”
Methohexital: a practical review for outpatient dental anesthesia.“Perfusion of slices with 10 to 100 microM MTH caused no significant change in glutamatergic transmission in the hippocampal CA1 region, but enhanced gamma-aminobutyric acid (GABA)A-mediated inhibitory postsynaptic currents and induced spontaneous inhibitory postsynaptic currents in neocortical and hippocampal CA1 neurons.”
Multiple actions of methohexital on hippocampal CA1 and cortical neurons of rat brain slices.“2 A high, supra‐anaesthetic concentration of methohexitone increased the uptake of both d‐aspartate and GABA.”
“4 Thiopentone, pentobarbitone, methohexitone and hydroxydione inhibited K+‐stimulated GABA and D‐aspartate release.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback