Possible Interaction: Gamma-Aminobutyric Acid and Methionine

“ GABA and methionine showed a significant correlation with the indirect aggression score.”

“The dose-response curve for GABA in the presence of 10−3 M PC-G was shifted rightward and there was a decrease in maximum response.”

“H and M potently enhanced the potentiating effect of 200 nM GABA on [3H]FNM binding with EC50 values of 0.61 μM and 1.6 μM using forebrain membranes, with maximal enhancements of 33 and 47%, respectively.”

“Using cerebellar membranes, the corresponding IC50 values were 5.3 and 4.8 μM. These inhibitory … were reversed by the potent GABAA receptor blocker R5135 (10 nM), suggesting that H and M allosterically increase the affinity … GABAA receptors for GABA and MUS by binding to … in GABAA receptor complexes.”

“GABA seems to have a direct stabilizing effect on ODC, since the turnover of the enzyme was slowed almost twofold when measured in cells treated with 10−2 M GABA.”

“At higher doses (3 × 10−5 to 10−3 M ), the effect of GABA gradually diminished.”

“Exposure of cultured rat astrocytes to GABA (10−7 to 10−5 M ) induced a dose‐related inhibition of endozepine secretion.”

“The inhibitory effect of GABA (10−5 M) was mimicked by the GABAB receptor agonist baclofen ( 10−5 M).”

“Like 2-hydroxy-saclofen, bicuculline 10−5 M ) had a profound cross-desensitizing effect on the LMBW to subsequent exposures to GABA and ACh.”

“The gastrin and somatostatin responses to 10–4 M GABA were completely inhibited by the GABAA antagonist bicuculline ( 10–5 M ) and the cholinergic blocker atropine (10–7 M), whereas the GABAB antagonist CGP 35348 (5 × 10–5 M) was ineffective.”

“A low concentration of the anesthetic (10-6 M ) reduced the dissociation constant for GABA from 8.2 × 10-6 to 4.2 × 10-6 M without a significant effect on the Hill coefficient.”

“Incubation of these cells in the presence of 10−−5 M GABA produced several responses.”

“ GABA (10 −4 M) evoked a depolarization of the primary afferents and at concentrations of 10 −6 , 10 −5 and 10 −4 M reduced DRP amplitude by 14, 39 and 45%, respectively.”