Possible Interaction: Gamma-Aminobutyric Acid and Methamphetamine

“Disulfiram or gamma-aminobutyric acid (GABA)-ergic medications can also affect the reinforcement value or effects of cocaine or methamphetamine.”

“These results indicated a compensatory upregulation of GABA production and its functions in testis after METH exposure.”

“Our findings indicate, for the first time, that methamphetamine decreases striatal glutamine, glutamate and GABA levels, as well as glutamine/glutamate and GABA/glutamate ratios, while serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels remain unchanged.”

“The present study demonstrated that both the excitatory NMDA system and the inhibitory GABA system are involved in the proconvulsive effect of MA during prenatal and partially also postnatal development in female rats.”

“Both methylphenidate and methamphetamine , dopamine reuptake blockers, inhibited by 30% high K(+)-evoked GABA release; the inhibition was blocked by L-745,870.”

“Iontophoretic application, with increasing currents, of GABA produced a progressive inhibition of unit activity in control animals, an effect that was significantly reduced in rats pretreated with methamphetamine.”

“These results support the hypothesis that long-term administration of methamphetamine increases the activity of the striatonigral GABA system and thereby reduces the sensitivity of postsynaptic GABA receptors in the SNR.”

“Additionally, METH decreased extracellular GABA concentrations in the ventromedial thalamus (VM).”

“In contrast, the effect of K+‐depolarization on glutamate, aspartate and GABA levels was increased following repeated administration of methamphetamine.”

“ Methamphetamine (100 microM) inhibited by 46% the release of [3H]GABA.”

“Peripheral injection of the dopaminergic stimulant methamphetamine induced a short (lasting approximately 20 min) 4-5 fold increase in GABA release in the intact globus pallidus and a longer (lasting longer than 80 min) increase in the substantia nigra.”