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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Mefenamic Acid

Research Papers that Mention the Interaction

MFA also enhanced GABA‐activated responses and directly activated α1β2/β3 GABAA receptors, but inhibited responses to GABA on α1β1 constructs (IC50 = 40 ± 7.2 μm).
The European journal of neuroscience  •  1999  |  View Paper
Fenamates mefanamic and niflumic acids (MFA and NFA) induced dual potentiating and inhibitory effects on GABA currents recorded in isolated cerebellar Purkinje cells using the whole-cell patch-clamp and fast-application techniques.
Neuropharmacology  •  2019  |  View Paper
For example, 10 microM mefanamic acid potentiated 10 microM GABA responses by approximately 300% (EC50 approximately 5 microM) and inhibited maximal responses by 30% (IC50 approximately 30 microM).
The Journal of pharmacology and experimental therapeutics  •  1994  |  View Paper
GABA evoked concentration-dependent currents that were inhibited by the convulsants, bicuculline and picrotoxin, and potentiated by the positive allosteric modulators, diazepam, chlordiazepoxide, phenobarbital, allopregnanolone and mefenamic acid , consistent with native neuronal GABAA receptors.
Cells  •  2021  |  View Paper