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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Mefenamic Acid
Research Papers that Mention the Interaction
“ MFA also enhanced GABA‐activated responses and directly activated α1β2/β3 GABAA receptors, but inhibited responses to GABA on α1β1 constructs (IC50 = 40 ± 7.2 μm).”
Subunit‐selective modulation of GABAA receptors by the non‐steroidal anti‐inflammatory agent, mefenamic acid“Fenamates mefanamic and niflumic acids (MFA and NFA) induced dual potentiating and inhibitory effects on GABA currents recorded in isolated cerebellar Purkinje cells using the whole-cell patch-clamp and fast-application techniques.”
The mechanisms of potentiation and inhibition of GABAA receptors by non-steroidal anti-inflammatory drugs, mefenamic and niflumic acids“For example, 10 microM mefanamic acid potentiated 10 microM GABA responses by approximately 300% (EC50 approximately 5 microM) and inhibited maximal responses by 30% (IC50 approximately 30 microM).”
“ GABA evoked concentration-dependent currents that were inhibited by the convulsants, bicuculline and picrotoxin, and potentiated by the positive allosteric modulators, diazepam, chlordiazepoxide, phenobarbital, allopregnanolone and mefenamic acid , consistent with native neuronal GABAA receptors.”
An Electrophysiological and Pharmacological Study of the Properties of Human iPSC-Derived Neurons for Drug Discovery
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