Possible Interaction: Gamma-Aminobutyric Acid and Lorazepam

“Furthermore, higher sensorimotor GABA ] was associated with higher cortical inhibition (SICI) following lorazepam administration , suggesting that baseline sensorimotor [GABA] may be valuable in predicting pharmacological or neuromodulatory treatment response.”

“Herein, we investigate to what extent enhanced inhibition induced by lorazepam , a benzodiazepine facilitating the fixation of GABA on GABAA receptors, modifies the balance between motion integration and motion segmentation at the behavioural level.”

“These results suggest that lorazepam might specifically modulate the saliency of line-ends, presumably because processing these features involves inhibitory mechanisms using GABA as a neuromediator, and in turn modify the balance between motion integration and segmentation.”

“Results Intramuscular injection of GABA alone was reported to be significantly more painful, in a concentration related manner, than saline control injections, and this pain was further increased by co-injection of lorazepam with GABA.”

“As predicted by a model of neural interactions underlying bistability, both higher GABA concentrations in visual cortex and lorazepam administration induced slower perceptual dynamics, as reflected in a reduced number of perceptual switches and a lengthening of percept durations.”

“Based on the fact that lorazepam increased the affinity of gamma-aminobutyric acid (GABA) for the GABAA-receptor and its effects on the utriculi, the site of action seems to be the lateral vestibular nucleus.”