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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Lidocaine
Research Papers that Mention the Interaction
“The voltage‐sensitive sodium channel (VSSC) blocker lidocaine inhibited the firing rate of VTA GABA neurons at all doses tested (0.25–2.0 mg/kg).”
Cocaine disinhibits dopamine neurons in the ventral tegmental area via use‐dependent blockade of GABA neuron voltage‐sensitive sodium channels“Results are as follows: (1) The expression of GABA in the NaSA and NaSA + lidocaine groups decreased remarkably compared with that in the control group; there was no noticeable difference between the NaSA and NaSA + lidocaine groups.”
“ Lidocaine reversibly depressed IGABA evoked by 10 microM GABA , with an IC50 of 9.8 mM. In the presence of 3 mM lidocaine, 0.3 mM cocaine depressed IGABA (10 microM GABA) to 30+/-7%.”
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