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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Levodopa
Research Papers that Mention the Interaction
“ GABA , the inhibitory neuromodulator for baroreflex in NTS, tonically functions to inhibit, via GABAA receptors, L-DOPA release and depressor responses to levodopa.”
“ Levodopa inversely releases GABA.”
NEUROBIOLOGY OF l-DOPAergic SYSTEMS“The priming process involved in peak-dose dyskinesia is as follows: (1) marked fluctuation of dopamine concentration occurs in the synaptic clefts of striatal … increased production of GABA in the spiny neurons and excessive storage of GABA in their axon terminals, (4) following this, each dose of levodopa … GABA ….”
“ GABA decreases TD but is ineffective against L-dopa IM.”
“Moreover, l-dopa treatment increased histamine and GABA levels.”
Neurochemical, neurobehavioral and histochemical effects of therapeutic dose of l-dopa on striatal neurons in rats: Protective effect of virgin coconut oil.“Overall, our results indicate that chronic L-DOPA treatment , besides normalizing the altered levels of some amino acids after 6-OHDA, robustly increases striatal GABA and tyrosine levels which may in turn contribute to the development of L-DOPA-induced dyskinesia.”
“However, we observed an interaction of lesion and treatment whereby, among lesioned rats, l-DOPA given acutely (1 d) or chronically (14–16 d) reduced glutamate efflux and enhanced GABA efflux.”
“In parkinsonian rats, l-DOPA administration reduced M1 glutamate efflux and enhanced GABA efflux, coincident with the emergence of dyskinetic behaviors.”
“ Levodopa lowered metabolites concentrations in the striatum of MPTP‐lesioned mice (Glu: 20.2 ± 0.8 vs 11.2 ± …), p < 0.001; Gln: 5.4 ± 1.6 vs 1.6 ± 0.4 mM (+ Ldopa), p < 0.05; GABA : 3.6 ± 0.8 vs 1.… mM (+ Ldopa), p < 0.01).”
“Results suggest that L-DOPA acting as D2-like agonist inhibits GABA release in the rat globus pallidus and induces turning behavior in rats with unilateral lesions of the dopamine innervation.”
“significantly increases GABA levels in the SNr of rats treated with a daily repeated administration of L-DOPA (50 mg/kg, i.p.).”
“In the NTS, GABA tonically functions to inhibit via GABAA receptors L-DOPA release and depressor responses to L-DOPA , whereas L-DOPA induces GABA release.”
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