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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
supplement:
Levocarnitine
Research Papers that Mention the Interaction
“ LC act as an antioxidant and modulates the levels of neurochemicals such as glutamate, GABA , NO etc.”
Anxiolytic like effect of L-Carnitine in mice: Evidences for the involvement of NO-sGC-cGMP signaling pathway“Isolated rat cerebral cortex … were able to accumulate L-carnitine and this process was competitively inhibited by 1 mM gamma-aminobutyric acid (GABA) with a shift of Km from 7.8 +/- 1.9 mM to 14.6 +/- 4.0 mM. Addition of GABA also affected distribution of carnitine derivatives.”
“ GABA was the most potent inhibitor of L-carnitine uptake.”
“The results indicate that the uptake of L-carnitine by rat cortical neurones occurs in part by a process that can be potently inhibited by GABA and GABA uptake blockers.”
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