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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Levetiracetam
Research Papers that Mention the Interaction
“Although the underlying mechanism of action of levetirace-tam is unknown, the metabolism of GABA appears to be involved.”
Levetiracetam in L-dopa-induced dyskinesia.“ Levetiracetam binds to a specific site in the brain, influences intracellular calcium currents and reverses negative allosteric modulators of GABA‐ and glycine‐gated currents in vitro.”
“It has been argued that LEV can act on the N-type Ca channel and can reverse the gammaaminobutyric acid ( GABA ) and glycine-gated currents [1].”
“Furthermore, LEV restored the Glu/GABA ratio to approximately the control level and significantly increased the GABA concentration after the initiation of high-K+ conditions.”
Effect of levetiracetam on extracellular amino acid levels in the dorsal hippocampus of rats with temporal lobe epilepsy.“The suppression of glutamate excitation and the enhancement of GABA inhibition in the rats with continual LEV administration is a result of the up-regulation of glutamate and GABA transporters with the down-regulation of GTRAP3-18.”
“When GABA turnover was estimated after inhibition of GABA-T by aminooxyacetic acid (AOAA), treatment with levetiracetam (given 15 min prior to injection of AOAA) significantly reduced GABA turnover in the striatum.”
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