Possible Interaction: Gamma-Aminobutyric Acid and Leptin

“Therefore, these results indicate that leptin might inhibit fasting‐triggered activation of PVN neurons via presynaptic GABA synaptic functions which might be partially blocked by pharmacological activating GABA‐B. Our findings identify the role of leptin in the regulation of food intake.”

“ GABA correlated positively with chemerin, leptin , Fetuin A and endotoxin.”

“These results suggest that leptin suppresses IC excitation by facilitating GABA release in FSN→PN connections, which may not occur under a hunger state.”

“Their work suggests that a portion of leptin ’s antiobesity effectsaremediatedbysynapticreleaseofaminobutyric acid ( GABA ) from the specific subset of hypothalamic GABAergic neurons that also express leptin receptors.”

“These results demonstrate that GABA plays an important role in mediating leptin action.”

“The levels of hypothalamic GABA release were different in the two groups; whereas in prepubertal rats the hypothalamic release of GABA increased with leptin administration, the neurotransmitter release decreased in the peripubertal group.”

“ Leptin enhances the activity of these GABA neurons and thereby inhibits nucleus accumbens-projecting DA neurons.”

“Vong et al. [3] previously showed that LepR neurons can be broadly distinguished in glutamatergic and GABAergic, and that a large effect of leptin action may be mediated via GABA.”