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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Lamotrigine
Research Papers that Mention the Interaction
“With long-term dosing and once target doses were achieved at 4 weeks, significant elevations in GABA were observed compared with baseline for all three drugs (topiramate 46%, gabapentin 25%, lamotrigine 25%).”
Modulation of cerebral GABA by topiramate, lamotrigine, and gabapentin in healthy adults“Further, GABA (50 mg/kg) and/or muscimol (0.05 mg/kg) pretreatment with sub effective dose gabapentin (50 mg/kg) and lamotrigine (20 mg/kg) significantly potentiated their protective effects which were significant as compared to their effect alone.”
Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity.“ LTG (0.1-300 microM) inhibited the release of aspartate, glutamate and GABA in a concentration-dependent manner.”
“Tentatively, simultaneous inhibition of GABA (gamma-aminobutyric acid) release might be critically involved in the prodystonic activity of lamotrigine.”
“ LTG is a less potent inhibitor of the release of γ‐aminobutyric acid ( GABA ), acetylcholine, noradrenaline, and dopamine.”
“LTG inhibited veratrine‐evoked release of glutamate and aspartate, with ED50 values of 21 μM for both amino acids, but LTG was less potent in the inhibition of GABA release (ED50= 44 μM).”
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