Possible Interaction: Gamma-Aminobutyric Acid and Kynurenic Acid

“Interestingly, kynA inhibited the peak amplitude (IC(50): 2.9 mM for 10 muM GABA ) and slowed the decay kinetics of GABA-evoked currents in cultured neurons.”

“Glutamate stimulates dopamine release by NMDA receptors, while blockade with kynurenic acid prevented the increase in dopamine and, in turn, of GABA and glutamate.”

“Applied to awake rats for 2 h by reverse dialysis, KYNA concentration-dependently and reversibly reduced extracellular GABA levels, with 300 nM KYNA causing a nadir of ∼45% of baseline concentrations.”

“ KYNA concentration‐dependently reduced GABA levels, with 300 nm KYNA causing a maximal reduction to ~60% of baseline concentrations.”

“Although significant changes in baseline arterial pressure and inspiratory activity were observed after topical applications of KYN and GABA , there are no guarantees that these treatments on the dorsal medulla were effective in depressing all neuronal activity at the NTS level.”

“This issue becomes more evident if it is considered that KYN and GABA applications on the dorsal surface of the medulla produced opposite effects on the arterial pressure.”