supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Ketanserin
Research Papers that Mention the Interaction
“Furthermore, ketanserin inhibited the pCA-evoked release of gamma-aminobutyric acid (GABA) and glycine, while tropisetron inhibited the pCA-evoked release of 5-HT.”
Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors.“In animals treated with both para-chlorophenylalanine and para-chloroamphetamine, ketanserin or the hallucinogenic agonist (2,5-dimethoxy-4-iodophenyl)-2-aminoethane (2C-I) each appeared to decrease stimulated GABA release but this was not significant.”
“In para-chlorophenylalanine-treated animals, stimulated GABA release in the presence of ketanserin remained depressed.”
“Under K+ stimulation, the antagonists ketanserin , spiperone, R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenethyl)]- 4-piperidinemethanol (MDL 100,907) and ritanserin inhibited GABA release by 12-31%.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback