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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Isoflurane
Research Papers that Mention the Interaction
“Results: Currents elicited by GABA were enhanced two- to four-fold by isoflurane , in a concentration-dependent manner.”
Isoflurane Potentiation of GABAA Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation“GABA induced currents in A549 cells, with half-maximal effective concentration of 2.5 µM. Isoflurane (0.1–250 µM) enhanced the GABA currents, which were partially inhibited by bicuculline.”
“A dual effect of anesthetics was postulated for both the nicotinic acetylcholine receptor (nAChR) and the GABA(A)R. We tested the hypothesis that, in addition to a blocking effect, ISO increases gamma-aminobutyric acid (GABA)-gated currents through recombinant GABA(A)R channels.”
“Currents induced by 0.01 mM GABA were potentiated by small ISO (twofold at 0.5 mM ISO) and inhibited by larger concentrations.”
“ ISO reduced the peak current elicited by 1 mM GABA.”
“Withdrawal of ISO and GABA induced rebound currents, suggesting an open-channel block by ISO.”
“ Isoflurane (at a concentration close to the EC50 for each subunit) increased the affinity of GABA for its receptor but depressed the maximal response (alpha beta gamma and alpha beta gamma delta).”
“Following sustained presence of GABA and high concentrations of isoflurane , simultaneous washout of both agents evoked a slowly decaying surge current, whose nature is controversial.”
“Inhaled anesthetics such as isoflurane act to enhance responses to submaximal concentrations of GABA , but it is not clear whether their effect is mediated by an increase in the binding of the agonist or by changes in receptor gating behavior.”
“When the mutant receptor was studied in the presence of isoflurane , the concentration–response curves for both GABA and P4S were shifted to the left (EC50 for GABA = 78 &mgr;m); the efficacy of P4S also increased significantly (&egr; = 0.40).”
“These simulations suggest that ISO slows the rate of GABA unbinding from the receptor.”
“A high concentration (2 mM) of isoflurane generated a surge current following the washout of GABA and the anesthetic.”
“Results:IL-1&bgr; increased the amplitude of current evoked by GABA in combination with clinically relevant concentrations of either etomidate (3 &mgr;M) or isoflurane (250 &mgr;M) (n = 5 to 17, P < 0.05).”
Inflammation Increases Neuronal Sensitivity to General Anesthetics“Conclusions: Isoflurane enhances both types of phasic GABAA receptor-mediated inhibition to similar degrees at amnesic concentrations.”
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