supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Indomethacin
Research Papers that Mention the Interaction
“The blockade of prostaglandin synthesis by indomethacin significantly decreased the gastroprotective action of GABA , Na- and Mg-valproate, but did not antagonize the effect of muscimol and diazepam.”
Effects of GABAergic drugs on ethanol-induced gastric lesions.“It is concluded that these effects of indomethacin are probably a result of GABA uptake inhibition.”
“Neurochemical … that indomethacin is a noncompetitive inhibitor of … mouse cortical synaptosomal uptake of [3H]GABA with a Ki of 0.7 mM. Indomethacin also displaced [3H]flunitrazepam and [3H]GABA binding to … cortical membranes in a competitive manner with IC50 values of 0.18 and 0.55 mM, respectively.”
“ Indomethacin pretreatment (5 mg/kg) significantly antagonized the hypothermia induced by GABA and muscimol.”
“ GABA diminished the number of the gastric ulcers induced by indomethacin sc 20 mg/kg, restraint or pyloric ligation.”
“Pretreatment with inhibitors of prostaglandin synthesis such as aspirin (3 X 10(-6) to 3 X 10(-4) M) and indomethacin (3 X 10(-6) M) reduced the contractile response to GABA in an irreversible manner and without affecting the relaxation induced by GABA.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback