Possible Interaction: Gamma-Aminobutyric Acid and Imipramine

“… imipramine resulted in a decrease in both the … deferens elicited by field stimulation to GABA and (−)-baclofen.2.In contrast, clonidine and isoproterenol effects were not altered by either treatment.3.This … nervous system is altered by chronic treatment with antidepressants, possibly by inducing changes in a postreceptor element.”

“These data indicate that repeated treatment of normal rats with imipramine results in a modification of the release mechanism of GABA from presynaptic terminals and its modulation by mGluR7 receptors as well as in an alteration in GABAA receptor subunit protein levels in the rat cerebral cortex.”

“Contrary to this, the concentrations of l-aspartate, l-serine, l-asparagine, glycine, l-glutamine, gamma-aminobutyric acid , l-threonine, l-arginine, l-proline, l-valine, and l-methionine in the hippocampus were decreased by chronic imipramine treatment.”

“Haloperidol and imipramine were able to affect the evoked release of both taurine and GABA.”

“Phenelzine and imipramine are efficacious in the treatment of depression and panic disorder and phenelzine has been reported to elevate GABA levels while imipramine enhances GABA release in rat brains.”

“The centrally acting drugs belonging to different groups--fluphenazine, trifluperidol, phthoracyzine, imipramine , diazepam, apomorphine, fentanyl, diphneylhydantoin, nonachlazine displayed in vitro an inhibitory effect on the uptake of gamma-aminobutyric acid by rat brain synaptosomes.”

“ Imipramine was a modest inhibitor of 3H‐GABA accumulation by whole brain synaptosomes; mianserin had no effect.”

“Considerable inhibition of the uptake of GABA by brain slices was observed with glutamic acid, imipramine , chlorpromazine, procaine, xylocaine or picrotoxin but not with acetylcholine, prostigmine, norepinephine, dopamine, chloral hydrate, chloretone, pentylentetrazol or methionine sulphoximine.”