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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Hydrogen Peroxide
Research Papers that Mention the Interaction
“Moreover, GABA also modulated Keap1-Nrf2 and Notch signaling pathways upon H2O2 stimulation, suggesting that GABA may exert its effect via multi mechanisms.”
A novel mechanism of Gamma-aminobutyric acid (GABA) protecting human umbilical vein endothelial cells (HUVECs) against H2O2-induced oxidative injury.“ H2O2 increased the release of glutamate and GABA from presynaptic terminals.”
Hydrogen peroxide modulates synaptic transmission in ventral horn neurons of the rat spinal cord“ H2O2 markedly potentiated GABA release , which was further enhanced about 1.5-fold by K+ stimulation (50 mM).”
“Whole cell recordings from identified cortical pyramidal … exposure to the FR-forming agent H2O2 (… gamma-aminobutyric acid-A- and gamma-aminobutyric acid-B-mediated inhibition to 35.3 +/- 13.4% and 13.7 +/- … and to 41.8 +/- 14.8% and 33.6 +/- 11.6% of control in thalamic neurons.”
“We hypothesized that the production of H2O2 and NH3 produced by monoamine oxidase (MAO) would lead to depletion of GABA and production of nitric oxide (NO.)”
“ GABA and SPER significantly prolonged the vase life and prevented degradation of proteins and chilling damage and increased capacity of detoxifying and scavenging of H2O2 and reactive oxygen species (ROS), led to alleviate the negative consequences of the senescence and CI.”
Pre-harvest spray of GABA and spermine delays postharvest senescence and alleviates chilling injury of gerbera cut flowers during cold storage“Concurrently GABA caused further increases in catalase and superoxide dismutase activities, which led to a significant reduction in hydrogen peroxide , superoxide anion and malondealdehyde contents under stress conditions.”
“… GABA significantly increased aboveground and root dry matter by 19.0% and 61.0%, promoted photosynthetic rate and chlorophyll content by 19.8% … 36.0%, fortified antioxidants (SOD, POD, CAT, GR, APX, VC) activities by 14.7–42.7%, and reduced the content of MDA, H2O2 , and O2− ….05).”
“Here, in the poplar woody plant under 200-mM NaCl conditions, the application of low (0.25 mM) and high (10 mM) exogenous GABA , compared to 0 mM, affected the accumulation of hydrogen peroxide and hormones, including ABA and ethylene, in different manners.”
“Catalase; EC 1.11.1.6 (CAT), l-ascorbate peroxidase; EC 1.11.1.11 (APX), and superoxide dismutase; EC 1.15.1.1 (SOD) activities were increased by GABA exposure in salt-supplemented plants that resulted in regulated hydrogen peroxide level.”
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