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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Hydrocortisone
Research Papers that Mention the Interaction
“Statistically significantly … MDD and HC were found regarding CSF 5-HIAA (n = 2/13 (15%)), … = 2/11 (18%)), MHPG (n = 1/8 (13%)), and GABA (n = 2/4 (50%)), while increased levels were reported regarding NE (n = … (50%)), MHPG (n = 1/8 (13%)) and DOPEG (n = 1/1 (100%)).”
Poor evidence for putative abnormalities in cerebrospinal fluid neurotransmitters in patients with depression versus healthy non-psychiatric individuals: A systematic review and meta-analyses of 23 studies.“As compared to females, the degree of a negative correlation between the blood content of GABA and ACTH (or cortisol ) in males was more pronounced.”
“Following transport, pigs fed GABA had decreased concentrations of serum malonaldehyde (MDA), adrenal cortical hormone and cortisol (p < .05).”
Effects of dietary γ-aminobutyric acid supplementation on antioxidant status, blood hormones and meat quality in growing-finishing pigs undergoing transport stress.“Since the equilibrium potential for Cl- (ECl) is near -20 mV, GABA released by the HC further depolarizes the HC.”
“ GABA enhanced the [3H]diazepam-displacing potencies of the 3S-enantiomers of the acetate, hemisuccinate , and (S)-alpha-methyl-beta-phenyl-propionate esters of oxazepam by a factor of about 1.5-1.6, whereas the GABA shifts for 3R-esters were about 1.2.”
“There was a sinistral shift … in the presence of 10 pM cortisol , with a significant potentiation of … lower dose range of GABA (3-30 microM), whereas 100 nM cortisol caused a non-parallel dextral shift of …, with a depression of the maximum GABA response indicative of non-competitive antagonism.”
“Voltage-clamp analyses showed that the inward current induced by an iontophoretic application of GABA (GABA current) was suppressed by prednisolone and hydrocortisone.”
“Km of [3H] GABA uptake by synaptosomes in the above mentioned brain regions under adrenalectomy decreases sharply; hydrocortisone administration increases Km of mediator uptake by hippocampus synaptosomes, and hydrocortisone in vitro increases Km of [3H] GABA uptake by hypothalamus synaptosomes.”
“The content of GABA decreases in the hippocampus and cortex and increases in the medulla oblongata 1 hour after injection of hydrocortisone (5 mg/100 g of mass).”
“The intracardiac injection (50 microgram/g) of GABA to Carps clearly inhibits the rise of the plasma cortisol level which occurs usually in response to the blood sampling manipulations.”
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