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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Gamma-Aminobutyric Acid
supplement:
Homocysteine
Research Papers that Mention the Interaction
“Interestingly, elevated levels of homocysteine (Hcy), also known as hyperhomocysteinemia (HHcy), antagonizes beta-2 adrenergic receptors (β2AR), gamma amino butyric acid (GABA), and peroxisome proliferator-activated receptor-gamma (PPARγ) receptors.”
Exercise mitigates the adverse effects of hyperhomocysteinemia on macrophages, MMP-9, skeletal muscle, and white adipocytes.“ Hcy competes with GABA at the GABA(A) receptor and affects the CNS function.”
Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery“These data suggest that the imbalance in excitatory:inhibitory neurotransmission in the hippocampus caused by these alterations in extracellular levels of neuroexcitatory (i.e. aspartate) and neuroinhibitory (i.e. GABA ) transmitters could underly the epileptic effect of homocysteine.”
“The vesicular uptake of gamma-aminobutyric acid (GABA) was also inhibited by kainate and L-homocysteate.”
“Increasing doses of L-HCA injected into the anterior striatum resulted in dose-dependent reductions in both substance P-like immunoreactivity (SP-LI) and gamma-aminobutyric acid (GABA) while there was a relative sparing of both somatostatin-like immunoreactivity (SS-LI) and neuropeptide Y-like immunoreactivity (NPY-LI).”
“The excitatory mechanisms of homocysteine through activation of the N-methyl-d-aspartate receptor in brain tissue might alter levels of glutamate and γ-aminobutyric acid.”
Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue
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