supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
supplement:
Histidine
Research Papers that Mention the Interaction
“Mutation of serine residue 294 within the TM2 to histidine or tyrosine increased the potency of GABA and decreased positive modulation by isoflurane.”
Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit“Introduction of a histidine (T349H) at the extracellular end of transmembrane segment (TM) 7 together with a histidine (E370H) or a cysteine (Q374C) at the extracellular end of TM 8 resulted in potent inhibition of [3H]GABA uptake by Zn(2+) (IC(50) = 35 and 44 microM, respectively).”
Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents.“The substitution of histidine with citruline, aspartic acid, norleucine or diaminobutyric acid in position 14 of the amino acid chain led to a considerable increase in potency, suggesting that amino acids located at this position might play a crucial role where the strength of short analogues is concerned.”
“ L-Histidine enhanced the inhibitory actions of GABA , muscimol and beta-alanine rather than that of glycine on spinal neurones in pentobarbitone-anaesthetised cats.”
“Interestingly, though amino acids such as alanine, histidine , proline and serine were not affected by liver diseases, but were significantly correlated with GABA level.”
Role of plasma amino acids and gaba in alcoholic and non-alcoholic fatty liver disease-a pilot study
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback