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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Histamine
Research Papers that Mention the Interaction
“Histamine has generally excitatory effects on target neurons, but paradoxically, histamine neurons may also release the inhibitory neurotransmitter GABA.”
Histamine: neural circuits and new medications“Interestingly, simultaneous application of histamine and GABA activated both PxHCLA and PxHCLB more strongly than either neurotransmitter individually; histamine and GABA may have synergistic effects on PxHCLs in the regions where they co-localize.”
“ Histamine directly activated (Z)β3 and β3 homooligomers and potentiated GABA actions in α1(Z)β3 heterooligomers.”
“Endogenous NO modulates the release of acetylcholine, glutamate, aspartate, GABA , serotonin, histamine in distinct brain areas.”
“We found that histamine potentiated the whole-cell responses to GABA for all tested subunit combinations.”
“In U373 MG cells, a line derived from a human astrocytoma, histamine stimulated the release of [3H]gamma-aminobutyric acid ([3H]GABA) in a concentration-dependent manner (286 +/- 23% of basal release at 1 mM histamine).”
“Taken together, these results indicate that histamine stimulates [3H]GABA release by increasing [Ca2+]i.”
“ Histamine regulates release of neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid (GABA), glutamate and also is involved in several functions in central nervous system (CNS).”
Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice.“ Histamine inhibited the evoked release of GABA , both through a direct action on presynaptic H3 receptors (presumably located on GABAergic terminals), and through a novel, indirect pathway that involved the increased release of glycine by activation of postsynaptic H1/H2 receptors (presumably on glycinergic neurons).”
“In addition, an inhibition of amygdaloid kindled seizures induced by histamine is closely related with the action of GABA.”
“7 In conclusion, histamine inhibits spontaneous GABA release from presynaptic nerve terminals projecting to VMH neurones by inhibiting presynaptic P/Q‐type Ca2+ channels via a G‐protein coupled to H3 receptors and this may modulate the excitability of VMH neurones.”
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