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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Hiperforina

Research Papers that Mention the Interaction

However, hyperforin inhibits also the uptake of gamma-aminobutyric acid (GABA) and L-glutamate.
CNS drug reviews  •  2004  |  View Paper
Although we noted enhanced glutamate, aspartate and GABA release under the influence of hyperforin , the release of various other amino acids was not enhanced.
Pharmacopsychiatry  •  2001  |  View Paper
We have recently shown that hyperforin , a major active constituent of St. John's Wort, not only inhibits the neuronal uptake of serotonin, norepinephrine and dopamine, but also that of L-glutamate and GABA.
Neuropsychopharmacology  •  2000  |  View Paper
Although 1 microM hyperforin inhibited virtually all investigated conductances ( GABA > or = I(Ca(N)) > I(Na) > I(Ca(P) > or = AMPA > or = I(K(A)) > NMDA > I(K(DR))), its effects on several of them could not be reversed by repeated washings.
Life sciences  •  1999  |  View Paper