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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Hiperforina
Research Papers that Mention the Interaction
“However, hyperforin inhibits also the uptake of gamma-aminobutyric acid (GABA) and L-glutamate.”
Role of hyperforin in the pharmacological activities of St. John's Wort.“Although we noted enhanced glutamate, aspartate and GABA release under the influence of hyperforin , the release of various other amino acids was not enhanced.”
Stimulation of glutamate, aspartate and gamma-aminobutyric acid release from synaptosomes by hyperforin.“We have recently shown that hyperforin , a major active constituent of St. John's Wort, not only inhibits the neuronal uptake of serotonin, norepinephrine and dopamine, but also that of L-glutamate and GABA.”
“Although 1 microM hyperforin inhibited virtually all investigated conductances ( GABA > or = I(Ca(N)) > I(Na) > I(Ca(P) > or = AMPA > or = I(K(A)) > NMDA > I(K(DR))), its effects on several of them could not be reversed by repeated washings.”
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