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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Halothane

Research Papers that Mention the Interaction

In conclusion, the present study suggests that sevoflurane and halothane increase the accumulation of GABA by inducing the reverse transport of this neurotransmitter.
The accumulation of [3H]GABA was significantly increased by sevoflurane (0.058, 0.11, 0.23, 0.46, and 0.93 mM) and halothane (0.006, 0.012, 0.024, 0.048, 0072, and 0.096 mM) with an EC50 of 0.26 mM and 35 μM, respectively.
Cellular and Molecular Neurobiology  •  2013  |  View Paper
Halothane and propofol enhance the activity of the gamma-aminobutyric acid (GABA) system, which is one of the most important systems in the mechanism of anesthesia.
Anesthesia and analgesia  •  2004  |  View Paper
Halothane may cause a conformational change of membrane proteins, particularly of the nicotinic receptor (and at higher concentrations of GABA and 5-hydroxytryptamine receptors); thus, stimulation may be prevented by an inhibition of agonist-receptor interaction.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Halothane and isoflurane, but not thiamylal or thiopental, significantly inhibited uptake by COS cell systems of GABA , dopamine and glutamic acid in a concentration-dependent manner within clinically relevant ranges for anesthesia induced by these agents.
Similarly, in synaptosomes halothane and isoflurane but not thiopental significantly suppressed the uptake of GABA and glutamic acid, respectively.
Toxicology letters  •  2001  |  View Paper
These findings indicate that pentobarbital and propofol produce inhibitory actions due to enhancement in the GABA(A) receptor; that ketamine reduces NMDA receptor-mediated responses and enhances GABA(A) receptor-mediated responses; and that halothane and isoflurane modulate GABA(A ), NMDA, and non-NMDA receptor-mediated synaptic transmission.
Anesthesia and analgesia  •  1999  |  View Paper
Halothane (2.1%) did not shift the ED50 of IVM, but was antagonistic to GABA.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1990  |  View Paper
Halothane (0.86 mM), isoflurane (0.96 mM), and enflurane (1.89 mM), each equivalent to … concentration (MAC) units, augmented the sustained current evoked by 3 times 10−6 M GABA to 330‐350% of control and the peak current …−5 M of GABA to 136‐145% of control.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1989  |  View Paper
Halothane anesthesia depressed the activity of these neurons, presumably by releasing GABA from interneurons.
Life sciences  •  1984  |  View Paper
For instance, [3H]gamma-aminobutyric acid release in the dorsal raphe was enhanced by halothane anesthesia.
The Journal of pharmacology and experimental therapeutics  •  1983  |  View Paper
In brain slices, halothane was shown to inhibit the metabolic breakdown of GABA (μ-aminobutyric acid), an inhibitory neurotransmitter.
Anesthesiology  •  1981  |  View Paper
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